Most interestingly, disease predisposing alleles for IPF are opposite to those for COPD or lung cancer. These six key genes expressed increasingly in a higher glioma grade, shown in Figures 6(a)–6(f) (, ).
Kai Wang, 1 Robert Baldassano, 2 Haitao Zhang, 1 Hui-Qi Qu, 5, 6 Marcin Imielinski, 1 Subra Kugathasan, 7 Vito Annese, 8, 9 Marla Dubinsky, 10, 11 Jerome I. Rotter, 10, 11 Richard K. Russell, 12 Jonathan P. Bradfield, 1 Patrick M.A.
This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. (a b, c g, h i) The differences of gene expression of CAMK2D (a), EIF3K (b), MPC2 (c), MYL12B (g), PAM (h), and SLC35B4 (i) in schizophrenia and control. CGGA, another brain tumor database, stored Chinese glioma datasets over 2,000 samples with mRNA sequencing, mRNA microarray, and matched clinical data to benefit the correlation and survival analysis. English Dictionary antonyms of Genetic Disease. 2020, Article ID 3656841, 13 pages, 2020. https://doi.org/10.1155/2020/3656841, 1Department of Psychiatry, The Second People’s Hospital of Hunan Province, The Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China, 2Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Rd., Changsha 410008, China, 3Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, 110 Xiangya Rd., Changsha 410008, China, 4National Clinical Research Center for Geriatric Disorders, 87 Xiangya Rd., Changsha 410008, Hunan, China, 5Department of Neurology, Hunan Aerospace Hospital, Changsha, Hunan 410205, China, 6Engineering Research Center of Applied Technology of Pharmacogenetics, Ministry of Education, 110 Xiangya Rd., Changsha 410008, China, 7Department of Geriatric Urology, Xiangya International Medical Center, Xiangya Hospital, Central South University, Changsha 410008, China, 8Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Our data also indicated that SLC35B4 may be involved in pathogenesis of both schizophrenia and glioma, which provide hints that researchers may shed light on this glycosyltransferase gene for drug development of both two diseases. In areas not subjected to neurodegeneration BC-200 was normally expressed. (a) Cluster dendrogram of modules identified by WGCNA. In Alzheimer’s disease where neuronal function is seriously altered the result was opposite. Therefore, some factors specifically related to schizophrenia may influence the tumorigenesis. Threshold values were set as . Currently, there were limited mechanism studies of PAM on schizophrenia and glioma so that researchers may reveal deeper mechanisms that why an enzyme related to secreted peptides could conduct pathogenic or antipathogenic effects on the two diseases.
6 most significant DEGs were chosen as examples to exhibit the difference between schizophrenia and control (Figures 4(a)–4(c) and 4(g)–4(i), , ), and their survival curves of glioma (Figures 4(d)–4(f) and 4(j)–4(l)). HGNC, 1462. H. Li, J. Li, X. Yu et al., “The incidence rate of cancer in patients with schizophrenia: a meta-analysis of cohort studies,”, I. Elmaci and M. A. Altinoz, “Targeting the cellular schizophrenia.